As IBM Lotus Domino 8.5 now ships with the dojo Toolkit included you may have seen problems using your site using Internet Explorer 6. In my case, the website rendered just fine with Firefox and IE7 but in IE6 all I got was an empty page and an error message "operation aborted".
I found this thread and found it quite useful. Basically it recommends to close your base href tag in the page header. I found that moving the base href tag after the script tag is also a workaround for this problem.